Respiratory infections

Clinical information

Infections of the respiratory tract are mainly caused by viruses (e.g. SARS-CoV-2, influenza viruses, adenoviruses, RSV), but also bacteria (e.g. Legionella, Bordetella pertussis, Mycoplasma pneumoniae, Chlamydia pneumoniae).  Both the upper (e.g. nasal mucosa, paranasal sinuses) and the lower respiratory tracts (airways and bronchia) can be affected. The pathogens are mainly transmitted by droplet infection. Symptoms of respiratory infections include fever, cough, headaches and pain, pharyngitis, sinusitis, bronchitis or pneumonia.

Diagnostics

Since many respiratory pathogens cause similar symptoms, the diseases cannot usually be diagnosed based on the clinical image alone. Consequently, laboratory diagnostics are particular valuable. Direct pathogen detection (e.g. PCR) is in most cases the method of choice for the detection of acute respiratory infections.
Since antibodies are only formed some days or weeks following infection and the prevalence increases with age, an infection can often only be diagnosed retrospectively by investigation of a serum pair and detection of an IgG titer increase. Serological tests can also contribute to epidemiological monitoring.

Techniques

Method
Parameter
Substrate
Species
EUROLINE
Bordetella pertussis
(FHA, PT, ACT separately)
EUROLINE
EUROLINE
positive control serum: IgA, human, 50x concentrated
for Bordetella pertussis
EUROLINE
positive control serum: IgG, human, 50x concentrated
for Bordetella pertussis
ELISA
Bordetella pertussis
toxin
antigen-coated
microplate wells
ELISA
Bordetella pertussis
toxin
antigen-coated
microplate wells
ELISA
Bordetella pertussis
incl. IgG/RF absorbent
antigen-coated
microplate wells
ELISA
Bordetella
FHA
antigen-coated
microplate wells
ELISA
Bordetella
FHA
antigen-coated
microplate wells
PCR
EURORealTime MTB
ELISA
Legionella pneumophila
antigen-coated
microplate wells
ELISA
Legionella pneumophila
incl. IgG/RF absorbent
antigen-coated
microplate wells
IIFT
Legionella Mosaic 8
Legionella pneumophila mixture 5
Legionella longbeachae
3 BIOCHIPs per field:
bacterial smear
bacterial smear
verification BIOCHIP

L. pneumophila
L. longbeachae
IIFT
Legionella pneumophila
serotype 1
bacterial
smear
verification BIOCHIP
(2 BIOCHIPs per field)
Legionella
pneumophila
IIFT
Legionella pneumophila mixture 5 (serotype 1 - 7)
bacterial smear
functional BIOCHIP
Legionella pneumophila
ELISA
Mycoplasma pneumoniae
antigen-coated
microplate wells
ELISA
Mycoplasma pneumoniae
antigen-coated
microplate wells
ELISA
Mycoplasma pneumoniae
incl. IgG/RF absorbent
antigen-coated
microplate wells
ELISA
MERS coronavirus
antigen-coated
microplate wells
EUROLINE
Positive control serum (IgG, 50x concentrated)
for SARS CoV-2
ELISA
SARS-CoV-2
antigen-coated
microplate wells
ELISA
Quan-T-Cell SARS-CoV-2
To be used in combination with EQ 6841
PCR
EURORealTime SARS-CoV-2
EUROLINE
EUROLINE Anti-SARS-CoV-2 Profile ( IgG)
EUROLINE
ChLIA
Anti-SARS-CoV-2 RBD ChLIA (IgG)
Antigen-coated magnetic particles
ChLIA
Control set Anti-SARS-CoV-2 RBD ChLIA (IgG)
2 x 0.5 ml control 1/2
ELISA
SARS-CoV-2 QuantiVac
ELISA
SARS-CoV-2 NCP
PCR
EURORealTime SARS-CoV-2/Influenza A/B
ELISA
SARS-CoV-2 (Omicron Variante)
PCR
EURORealTime SARS-CoV-2 Fast
ELISA
Respiratory syncytial virus
(RSV)
antigen-coated
microplate wells
ELISA
Respiratory syncytial virus
(RSV)
antigen-coated
microplate wells
ELISA
Respiratory syncytial virus (RSV)
incl. IgG/RF absorbent
antigen-coated
microplate wells
ELISA
Adenovirus
antigen-coated
microplate wells
ELISA
Adenovirus
antigen-coated
microplate wells
ELISA
Adenovirus
incl. IgG/RF absorbent
antigen-coated
microplate wells
ELISA
Influenza virus type A
antigen-coated
microplate wells
ELISA
Influenza virus type A
antigen-coated
microplate wells
ELISA
Influenza virus type B
antigen-coated
microplate wells
ELISA
Influenza virus type B
antigen-coated
microplate wells
ELISA
Parainfluenza virus
types 1 - 4 (Pool)
antigen-coated
microplate wells
ELISA
Parainfluenza virus
types 1 - 4 (Pool)
antigen-coated
microplate wells
EUROArray
EUROArray PneuVir
ELISA
Quan-T-Cell ELISA
To be used in combination with ET 2606
antibody-coated
microplate wells
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